Saturday, March 31, 2007
Aromasin
Anabolic Steroids Profile Aromasin Exemestane Aromasin (Exemestane) is a steroidal suicide aromatase inhibitor, which means that it lowers estrogen production in the body by blocking the aromatase enzyme, the enzyme responsible for estrogen synthesization. (1)(2)(3) This stuff was developed to fight breast cancer in post-menopausal women, who need a particularly aggressive therapy, and for whom first line defenses such as SERMS (Tamoxifen) have not worked. This should be our first clue in inferring that this stuff is pretty strong, or at least stronger than some of the other compounds which are used to fight breast cancer. Aromasin and Side Effects Aromasin averages an 85% rate of estrogen suppression (4), so it´s clearly a very effective agent for bodybuilders and other athletes wanting to avoid estrogen related side effects such as gyno, acne, or water-retention brought on by aromatizing steroids. Specifically, Exemestane dose this by selectively inhibiting aromatase activity in a time-dependent and irreversible manner (hence the "suicidal" portion of it´s name, I guess).(7) As with most of the compounds in this class, it also causes a reasonable rise in testosterone levels (6), and as you may have guessed, this rise in testosterone means that Exemestane can also cause androgenic sides(8)(9)(10). As you can see from the chart below, exemestane is very effective at both lowering estrogen (estradiol) and raising testosterone: FIG. 1. Estrogen and androgen plasma levels after 10 d of daily exemestane (25 or 50 mg) in healthy young males (mean ± SD; n = 9-11). To convert to Systeme International units: estradiol, picomoles per liter (x3.671); estrone, picomoles per liter (x3.699); androstenedione, nanomoles per liter (*0.003492); and testosterone, nanomoles per liter (x0.03467). (13) So we can see that 25mgs is a very effective dose from that chart, right? As an added benefit, exemestane not only increases testosterone and lowers estrogen, but it also increases IGF levels (11).Additionally Worth noting is that Aromasin may possibly be less harsh on blood lipids (14)than some of the other (similar) compounds we use in the world of bodybuilding or athletics (other AI´s). It also has, at best no effect on IGF, and at worst could lower (13) it. AI´s are very tricky with regards to inconsistencies in IGF levels. Unfortunately, you need to take Exemestane for a week to reach steady blood plasma levels of it, and exemestane has a ½ life of 27 hours (12.). The ability of exemestane to lower estrogen levels by the aforementioned 85% makes it a very nice choice for use in any cycle where aromatizing steroids are used. In addition, since it´s not too harsh at all on blood lipid profiles, it´s a very good choice for longer cycles. It´s ability to raise both testosterone levels also seem to suggest that it would be a very nice addition to a Post-Cycle-Therapy (PCT).
Wednesday, March 28, 2007
HCG (Human Chorionic Gonadotropin)
HCG (Human Chorionic Gonadotropin)
Quick overview:
Active Life: 64 hours
Drug Class: Leutenizing Hormone (LH) - Gonadotropin
Average Dose: debatable
Acne: Yes
Water Retention: Yes
High Blood Pressure: Yes
Liver Toxic: No
Aromatization: No, but it will raise testosterone levels and increased aromatization may occur.
Chorionic gonadotropin is a hormone found in the female body during the early months of pregnancy (it is produced in the placenta). It is in fact the pregnancy indicator looked at by the over the counter pregnancy test kits, as due to its origin it is not found in the body at any other time. Blood levels of this hormone will become noticeable as early as seven days after ovulation. The level will rise evenly, reaching a peak at approximately two to three months into gestation. After this point, the hormone level will drop gradually until the point of birth. As a prescription drug, HCG offers us some interesting benefits. In the United States, we have the two popular brands, Pregnyl, made by Organon, and Profasi, made by Serono. These are FDA approved for the treatment of undescended testicles in young boys, hypogonadism (underproduction of testosterone) and as a fertility drug used to aid in inducing ovulation in women. When prepared as a medical item, this hormone comes from a human origin. Although there is often a fear of biological origin products, there is little research to be found regarding pathogen or sterility problems with HCG. The problems seen with human origin growth hormone are certainly not to be repeated with HCG, as this compound is obtained in a much different way.
While HCG offers the female no performance enhancing ability, it does prove very useful to the male steroid user. The obvious use of course being to stimulate the production of endogenous testosterone. The activity of HCG in the male body is due to its ability to mimic LH (luteinizing hormone), a pituitary hormone that stimulates the Leydig's cells in the testes to manufacture testosterone. Restoring endogenous testosterone production is a special concern at the end of each steroid cycle, a time when a subnormal androgen level (due to steroid induced suppression) could be very costly. The main concern is the action of cortisol, which in many ways is balanced out by the effect of androgens. Cortisol sends the opposite message to the muscles than testosterone, or to breakdown protein in the cell. Left unchecked (by an extremely low testosterone level) in the body, cortisol can quickly strip much of your new muscle mass away.
The main focus with HCG is to restore the normal ability of the testes to respond to endogenous luteinizing hormone. After a long period of inactivity, this ability may have been seriously reduced. In such a state testosterone levels may not reach a normal point, even though the release of endogenous LH has been resumed. Many who have suffered severe testicular shrinkage may be able to relate, as it is often some time before normal testicle size and feelings of virility are restored if ancillary drugs had not been used. The excessive stimulation brought forth by administration of HCG can likewise cause the testicles to rapidly return to their normal size and level of activity. We are not simply looking for it to fix the problem however, as the resulting high testosterone level can itself trigger negative feedback inhibition at the hypothalamus. Estrogen production is also heightened with the use of HCG, due to its ability to increase aromatase activity in the Leydig's cells. This is due to the main action of HCG, namely the increase of cycIicAMP (a secondary messenger that regulates cellular activity). When stimulated by HCG, the ability of the testes to aromatize androgens could potentially be heightened several times greater than normal. This also may inhibit testosterone production, so we therefore use HCG only as a quick shock to the testes.
The usual protocol is to inject 1500-3000 I.U. every 4th or 5th day, for a duration usually no longer than 2 or 3 weeks. If used for too long or at too high a dose, the drug may actually function to desensitize the Leydig's cells to luteinizing hormone, further hindering a return to homeostasis. Timing the initial dose is also very crucial. If your were coming off a cycle of Sustanon for example, testosterone levels in your blood will likely stay elevated for at least 3 to 4 weeks after your last injection. Taking HCG on the day of your last shot would therefore be useless. Instead one would want to calculate the last week in which androgen levels are likely to be above normal, and begin ancillary drug therapy at this point. In this case HCG would be started around the third or fourth week. Likewise, after ending a cycle of Dianabol (an oral) your blood levels will be sub normal after the third day. Here you may want to begin HCG therapy a few days before your last intake of tablets, giving it a few days to take effect. One would also want to give some thought to the level of suppression that the cycle might have brought about. After an 8 week cycle of Equipoise for example, 1500-2500 I.U. would likely be a sufficient initial dosage. The lower amount of hormonal suppression one associates with this drug would probably not require much more. On the other hand, 750-1000mg of Sustanon per week might incline the user to inject a much larger HCG dose, perhaps as much as 5000 I.U. for the opening application. It may thereafter also be a good idea to reduce the dosage on subsequent shots, so as to step down the intake of HCG during the two or three weeks of intake.
As discussed above, HCG acts only to mimic the action of LH. It is likewise not the perfect hormone to combat testosterone suppression, and for this reason it is used most often in conjunction with estrogen antagonists such as Clomid, Nolvadex or cyclofenil. These drugs have a different effect on the regulating system, namely inhibiting estrogen-induced suppression at the hypothalamus. This of course also helps to restore the release of testosterone, although through a much different mechanism than HCG. A combination of both drugs appears to be very synergistic, HCG providing an immediate effect on the testes (shocking them out of inactivity) while the anti-estrogen helps later to block inhibition on the hypothalamus and resume the normal release of gonadotropins from the pituitary. The typical procedure involves giving the Clomid/Nolvadex dose from the start with HCG, but continuing it alone for a few weeks once HCG has been discontinued. This practice should effectively raise testosterone levels, which will hopefully remain stable once Clomid/Nolvadex have been discontinued. While unfortunately there is no way to retain all of the muscle gains produced by anabolic steroids, using ancillaries to restore a balanced hormonal state is the best way to minimize the loss felt with ending a cycle.
Quick overview:
Active Life: 64 hours
Drug Class: Leutenizing Hormone (LH) - Gonadotropin
Average Dose: debatable
Acne: Yes
Water Retention: Yes
High Blood Pressure: Yes
Liver Toxic: No
Aromatization: No, but it will raise testosterone levels and increased aromatization may occur.
Chorionic gonadotropin is a hormone found in the female body during the early months of pregnancy (it is produced in the placenta). It is in fact the pregnancy indicator looked at by the over the counter pregnancy test kits, as due to its origin it is not found in the body at any other time. Blood levels of this hormone will become noticeable as early as seven days after ovulation. The level will rise evenly, reaching a peak at approximately two to three months into gestation. After this point, the hormone level will drop gradually until the point of birth. As a prescription drug, HCG offers us some interesting benefits. In the United States, we have the two popular brands, Pregnyl, made by Organon, and Profasi, made by Serono. These are FDA approved for the treatment of undescended testicles in young boys, hypogonadism (underproduction of testosterone) and as a fertility drug used to aid in inducing ovulation in women. When prepared as a medical item, this hormone comes from a human origin. Although there is often a fear of biological origin products, there is little research to be found regarding pathogen or sterility problems with HCG. The problems seen with human origin growth hormone are certainly not to be repeated with HCG, as this compound is obtained in a much different way.
While HCG offers the female no performance enhancing ability, it does prove very useful to the male steroid user. The obvious use of course being to stimulate the production of endogenous testosterone. The activity of HCG in the male body is due to its ability to mimic LH (luteinizing hormone), a pituitary hormone that stimulates the Leydig's cells in the testes to manufacture testosterone. Restoring endogenous testosterone production is a special concern at the end of each steroid cycle, a time when a subnormal androgen level (due to steroid induced suppression) could be very costly. The main concern is the action of cortisol, which in many ways is balanced out by the effect of androgens. Cortisol sends the opposite message to the muscles than testosterone, or to breakdown protein in the cell. Left unchecked (by an extremely low testosterone level) in the body, cortisol can quickly strip much of your new muscle mass away.
The main focus with HCG is to restore the normal ability of the testes to respond to endogenous luteinizing hormone. After a long period of inactivity, this ability may have been seriously reduced. In such a state testosterone levels may not reach a normal point, even though the release of endogenous LH has been resumed. Many who have suffered severe testicular shrinkage may be able to relate, as it is often some time before normal testicle size and feelings of virility are restored if ancillary drugs had not been used. The excessive stimulation brought forth by administration of HCG can likewise cause the testicles to rapidly return to their normal size and level of activity. We are not simply looking for it to fix the problem however, as the resulting high testosterone level can itself trigger negative feedback inhibition at the hypothalamus. Estrogen production is also heightened with the use of HCG, due to its ability to increase aromatase activity in the Leydig's cells. This is due to the main action of HCG, namely the increase of cycIicAMP (a secondary messenger that regulates cellular activity). When stimulated by HCG, the ability of the testes to aromatize androgens could potentially be heightened several times greater than normal. This also may inhibit testosterone production, so we therefore use HCG only as a quick shock to the testes.
The usual protocol is to inject 1500-3000 I.U. every 4th or 5th day, for a duration usually no longer than 2 or 3 weeks. If used for too long or at too high a dose, the drug may actually function to desensitize the Leydig's cells to luteinizing hormone, further hindering a return to homeostasis. Timing the initial dose is also very crucial. If your were coming off a cycle of Sustanon for example, testosterone levels in your blood will likely stay elevated for at least 3 to 4 weeks after your last injection. Taking HCG on the day of your last shot would therefore be useless. Instead one would want to calculate the last week in which androgen levels are likely to be above normal, and begin ancillary drug therapy at this point. In this case HCG would be started around the third or fourth week. Likewise, after ending a cycle of Dianabol (an oral) your blood levels will be sub normal after the third day. Here you may want to begin HCG therapy a few days before your last intake of tablets, giving it a few days to take effect. One would also want to give some thought to the level of suppression that the cycle might have brought about. After an 8 week cycle of Equipoise for example, 1500-2500 I.U. would likely be a sufficient initial dosage. The lower amount of hormonal suppression one associates with this drug would probably not require much more. On the other hand, 750-1000mg of Sustanon per week might incline the user to inject a much larger HCG dose, perhaps as much as 5000 I.U. for the opening application. It may thereafter also be a good idea to reduce the dosage on subsequent shots, so as to step down the intake of HCG during the two or three weeks of intake.
As discussed above, HCG acts only to mimic the action of LH. It is likewise not the perfect hormone to combat testosterone suppression, and for this reason it is used most often in conjunction with estrogen antagonists such as Clomid, Nolvadex or cyclofenil. These drugs have a different effect on the regulating system, namely inhibiting estrogen-induced suppression at the hypothalamus. This of course also helps to restore the release of testosterone, although through a much different mechanism than HCG. A combination of both drugs appears to be very synergistic, HCG providing an immediate effect on the testes (shocking them out of inactivity) while the anti-estrogen helps later to block inhibition on the hypothalamus and resume the normal release of gonadotropins from the pituitary. The typical procedure involves giving the Clomid/Nolvadex dose from the start with HCG, but continuing it alone for a few weeks once HCG has been discontinued. This practice should effectively raise testosterone levels, which will hopefully remain stable once Clomid/Nolvadex have been discontinued. While unfortunately there is no way to retain all of the muscle gains produced by anabolic steroids, using ancillaries to restore a balanced hormonal state is the best way to minimize the loss felt with ending a cycle.
Monday, March 26, 2007
Sustanon 250
Sustanon 250
(testosterone)
This product was developed by Organon as an ideal HRT (Hormone Replacement Therapy) solution, and it was thought at the time that the different esters would be able to provide a constant release of Testosterone over a months time. Sustanon is a blend of different estered testosterones (4 of them): testosterone propionate - 30 mg, testosterone phenylpropionate - 60 mg, testosterone isocaproate - 60mg, and testosterone decanoate -100 mg.
This drug was highly sought after as a "superior" version of testosterone in the late 80´s and through the mid 90´s. No doubt this is partly due to the very nice write-up Dan Duchaine gave it in his newsletters. However, lets keep in mind that this drug was designed for convenience, not athletics or bodybuilding. The advantage to this drug, according to the manufacturer, is that it can be injected once a month, and the different esters would provide different timed releases over that month, and the patient would therefore only need to visit the doctor once a month for his shot. For athletes or bodybuilders (who routinely use between half a gram and a gram of testosterone per week), this product is really no better than any other form of injectable testosterone.
Lately, it seems that this product has fallen out of favor with Steroid.com members, as many feel that the inclusion of the Propionate and phenylpropionate estered forms of testosterone in this blend would necessitate shooting every other day. This stems from the fact that testosterone propionate would be shot every other day at least, and testosterone phenylpropionate would generally be shot every third day.
Sustanon will do exactly what other forms of testosterone will do:
Testosterone will cause both muscle growth as well as fat loss. It sends a message to muscle cells to store more contractile protein (called actin and myosin), thus making your muscles grow. It also protects your muscles from catabolic (muscle wasting) glucocorticoid hormones(1). Thus it is often said that testosterone is not only anabolic, but it is strongly catabolic. Not only does it cause an increase in size of the muscle fibres (hyperfascia) but it also can change the appearance and the actual number of muscle fibres (Hyperplasia)(2). Testosterone has the ability to increase erythropoiesis (red blood cell production) in your kidneys(4), and a higher Red Blood Cell (RBC) count may improve endurance by producing more highly oxygenated blood. More RBCs can also improve recovery from strenuous physical activity. Agression levels often rise dramatically with the use of any exogenous testosterone (3). Testosterone improves muscle contraction by increasing the number of motor neutrons in muscle(5) and improves neuromuscular transmission(6). It also promotes glycogen synthesis(7)
And, since Sustanon is simply a form of (well actually 4 forms of) testosterone, we also know that administration of this compound will produce a dose respondant curve. (10)A what? Yeah...basically a "dose respondant curve" is the fancy way of saying "the more you take, the bigger you get..."
This is true of Sustanon as well as for every form of testosterone, up to a point.
Unfortunately, Sustanon will also do all of the bad things that any form of testosterone is known for:
It will convert to the female hormone estrogen (via a mechanism known as aromatization) by the (you guessed it) aromatize enzyme. Excessive estrogen can lead to unwanted side effects, such as acne, the growth of breast tissue (gynecomastia), fat gain and reduced fat breakdown, loss of sex drive, testicular shrinkage and water retention. Water retention can increase blood pressure weakening blood vessels over time. Unfortunately, this isn´t all it does& it can also interact with the 5 alpha-reductase enzyme. This interaction converts the testosterone to Dihydro-testosterone (DHT), a more androgenic form of the parent hormone. DHT has a high binding affinity to the tissues of the scalp resulting in hair loss in loss in users who suffer from male pattern baldness. DHT can affect the prostate as well, making it larger. This swelling can cause the gland to press against the bladder causing urinary problems. Drugs called 5alpha-reductase inhibitors can prevent these symptoms without blocking testosterone´s anabolic effects.(8) Higher dosages of test can also negatively impact cholesterol, lowering HDL(9). Testosterone is probably the safest steroid around, but it can´t be taken lightly, and Sustanon is no different.
The principal drawback to Sustanon is it´s cost. It can cost between $5 an ampule and $12 an ampule. Compared with Omnadren, Testoviron, or even Sten (other testosterone products featuring various blends of Testosterone), the cost makes it prohibitive. An equal amount of an of the aforementioned products can be had for less than half the average cost of an amp of Sustanon. Sustanon, therefore, is no better or worse than any other form of testosterone... if the price is right.
17b-hydroxy-4-androsten-3-one
Testosterone base + 4 different esters
Propionate, Phenylpropionate, Isocaproate, Decanoate
Formula (base): C27 H40 O3
Molecular Weight (base): 288.429
Molecular Weight, Esters:
Propionate: 362.5082
Phenylpropionate: 438.6058
Isocaproate: 404.5886
Decanoate: 460.6958
Formula (base): C19 H28 O2
Melting Point (base): 155
Manufacturer: Organon
Effective Dose (Men): 500-2000mg/ week
Effective Dose (Women): Not recommended
Active life: Up to 3 weeks
Detection Time: 3+ months
Anabolic/Androgenic ratio:100/100
References:
Human Anatomy and Physiology, 6th Edition, John W. Hole jr.
J Appl Physiol 94: 2273-2281, 2003. First published February 14, 2003; doi:10.1152
Journal of Applied Physiology, Vol 77, Issue 1 23-29,
EFFECTS OF RECOMBINANT GROWTH HORMONE ON VISCERAL FAT ACCUMULATION: PILOT STUDY IN HIV-INFECTED ADOLESCENTS. J Clin Endocrinol Metab. 2005 Apr 19; [Epub ahead of print]
Measures of submaximal aerobic performance evaluate and predict functional response to growth hormone (HGH) treatment in HGH-deficient adults. J Clin Endocrinol Metab. 1999 Dec;84(12):4570-7.
Hormonal responses to consecutive days of heavy-resistance exercise with or without nutritional supplementation. J Appl Physiol, Oct 1998; 85: 1544 - 1555.
Hormonal and growth factor responses to heavy resistance exercise protocols. J Appl Physiol, Oct 1990; 69: 1442-1450
High dose growth hormone exerts an anabolic effect at rest and during exercise in endurance-trained athletes.J Clin Endocrinol Metab. 2003 Nov;88(11):5221-6.
Christ ER, Cummings MH, Westwood NB, Sawyer BM, Pearson TC, Sonksen PH, Russell-Jones DL. The importance of growth hormone in the regulation of erythropoiesis, red cell mass, and plasma volume in adults with growth hormone deficiency., J Clin Endocrinol Metab 1997 Sep;82(9):2985-90
The Journal of Clinical Endocrinology & Metabolism Vol. 87, No.8 3573-3577
Am J Physiol Endocrinol Metab. 2002 Mar;282(3):E601-7.
Testosterone blunts feedback inhibition of growth hormone secretion by experimentally elevated insulin-like growth factor-I concentrations.J Clin Endocrinol Metab. 2005 Mar;90(3):1613-7. Epub 2004 Dec 7.
Comparison of the Metabolic Effects of Raloxifene and Oral Estrogen in Postmenopausal and Growth Hormone-Deficient Women.J Clin Endocrinol Metab. 2005 Apr 26; [Epub ahead of print]
Serum insulin-like growth factor I levels in growth hormone-deficient adults: influence of sex steroids.Horm Res. 2004;62 Suppl 1:73-6.
Growth hormone enhances effects of endurance training on oxidative muscle metabolism in elderly women. Am J Physiol Endocrinol Metab, Nov 2000; 279: 989 - 996.
J Gerontol A Biol Sci Med Sci 1998 May;53(3):M183-7
(testosterone)
This product was developed by Organon as an ideal HRT (Hormone Replacement Therapy) solution, and it was thought at the time that the different esters would be able to provide a constant release of Testosterone over a months time. Sustanon is a blend of different estered testosterones (4 of them): testosterone propionate - 30 mg, testosterone phenylpropionate - 60 mg, testosterone isocaproate - 60mg, and testosterone decanoate -100 mg.
This drug was highly sought after as a "superior" version of testosterone in the late 80´s and through the mid 90´s. No doubt this is partly due to the very nice write-up Dan Duchaine gave it in his newsletters. However, lets keep in mind that this drug was designed for convenience, not athletics or bodybuilding. The advantage to this drug, according to the manufacturer, is that it can be injected once a month, and the different esters would provide different timed releases over that month, and the patient would therefore only need to visit the doctor once a month for his shot. For athletes or bodybuilders (who routinely use between half a gram and a gram of testosterone per week), this product is really no better than any other form of injectable testosterone.
Lately, it seems that this product has fallen out of favor with Steroid.com members, as many feel that the inclusion of the Propionate and phenylpropionate estered forms of testosterone in this blend would necessitate shooting every other day. This stems from the fact that testosterone propionate would be shot every other day at least, and testosterone phenylpropionate would generally be shot every third day.
Sustanon will do exactly what other forms of testosterone will do:
Testosterone will cause both muscle growth as well as fat loss. It sends a message to muscle cells to store more contractile protein (called actin and myosin), thus making your muscles grow. It also protects your muscles from catabolic (muscle wasting) glucocorticoid hormones(1). Thus it is often said that testosterone is not only anabolic, but it is strongly catabolic. Not only does it cause an increase in size of the muscle fibres (hyperfascia) but it also can change the appearance and the actual number of muscle fibres (Hyperplasia)(2). Testosterone has the ability to increase erythropoiesis (red blood cell production) in your kidneys(4), and a higher Red Blood Cell (RBC) count may improve endurance by producing more highly oxygenated blood. More RBCs can also improve recovery from strenuous physical activity. Agression levels often rise dramatically with the use of any exogenous testosterone (3). Testosterone improves muscle contraction by increasing the number of motor neutrons in muscle(5) and improves neuromuscular transmission(6). It also promotes glycogen synthesis(7)
And, since Sustanon is simply a form of (well actually 4 forms of) testosterone, we also know that administration of this compound will produce a dose respondant curve. (10)A what? Yeah...basically a "dose respondant curve" is the fancy way of saying "the more you take, the bigger you get..."
This is true of Sustanon as well as for every form of testosterone, up to a point.
Unfortunately, Sustanon will also do all of the bad things that any form of testosterone is known for:
It will convert to the female hormone estrogen (via a mechanism known as aromatization) by the (you guessed it) aromatize enzyme. Excessive estrogen can lead to unwanted side effects, such as acne, the growth of breast tissue (gynecomastia), fat gain and reduced fat breakdown, loss of sex drive, testicular shrinkage and water retention. Water retention can increase blood pressure weakening blood vessels over time. Unfortunately, this isn´t all it does& it can also interact with the 5 alpha-reductase enzyme. This interaction converts the testosterone to Dihydro-testosterone (DHT), a more androgenic form of the parent hormone. DHT has a high binding affinity to the tissues of the scalp resulting in hair loss in loss in users who suffer from male pattern baldness. DHT can affect the prostate as well, making it larger. This swelling can cause the gland to press against the bladder causing urinary problems. Drugs called 5alpha-reductase inhibitors can prevent these symptoms without blocking testosterone´s anabolic effects.(8) Higher dosages of test can also negatively impact cholesterol, lowering HDL(9). Testosterone is probably the safest steroid around, but it can´t be taken lightly, and Sustanon is no different.
The principal drawback to Sustanon is it´s cost. It can cost between $5 an ampule and $12 an ampule. Compared with Omnadren, Testoviron, or even Sten (other testosterone products featuring various blends of Testosterone), the cost makes it prohibitive. An equal amount of an of the aforementioned products can be had for less than half the average cost of an amp of Sustanon. Sustanon, therefore, is no better or worse than any other form of testosterone... if the price is right.
17b-hydroxy-4-androsten-3-one
Testosterone base + 4 different esters
Propionate, Phenylpropionate, Isocaproate, Decanoate
Formula (base): C27 H40 O3
Molecular Weight (base): 288.429
Molecular Weight, Esters:
Propionate: 362.5082
Phenylpropionate: 438.6058
Isocaproate: 404.5886
Decanoate: 460.6958
Formula (base): C19 H28 O2
Melting Point (base): 155
Manufacturer: Organon
Effective Dose (Men): 500-2000mg/ week
Effective Dose (Women): Not recommended
Active life: Up to 3 weeks
Detection Time: 3+ months
Anabolic/Androgenic ratio:100/100
References:
Human Anatomy and Physiology, 6th Edition, John W. Hole jr.
J Appl Physiol 94: 2273-2281, 2003. First published February 14, 2003; doi:10.1152
Journal of Applied Physiology, Vol 77, Issue 1 23-29,
EFFECTS OF RECOMBINANT GROWTH HORMONE ON VISCERAL FAT ACCUMULATION: PILOT STUDY IN HIV-INFECTED ADOLESCENTS. J Clin Endocrinol Metab. 2005 Apr 19; [Epub ahead of print]
Measures of submaximal aerobic performance evaluate and predict functional response to growth hormone (HGH) treatment in HGH-deficient adults. J Clin Endocrinol Metab. 1999 Dec;84(12):4570-7.
Hormonal responses to consecutive days of heavy-resistance exercise with or without nutritional supplementation. J Appl Physiol, Oct 1998; 85: 1544 - 1555.
Hormonal and growth factor responses to heavy resistance exercise protocols. J Appl Physiol, Oct 1990; 69: 1442-1450
High dose growth hormone exerts an anabolic effect at rest and during exercise in endurance-trained athletes.J Clin Endocrinol Metab. 2003 Nov;88(11):5221-6.
Christ ER, Cummings MH, Westwood NB, Sawyer BM, Pearson TC, Sonksen PH, Russell-Jones DL. The importance of growth hormone in the regulation of erythropoiesis, red cell mass, and plasma volume in adults with growth hormone deficiency., J Clin Endocrinol Metab 1997 Sep;82(9):2985-90
The Journal of Clinical Endocrinology & Metabolism Vol. 87, No.8 3573-3577
Am J Physiol Endocrinol Metab. 2002 Mar;282(3):E601-7.
Testosterone blunts feedback inhibition of growth hormone secretion by experimentally elevated insulin-like growth factor-I concentrations.J Clin Endocrinol Metab. 2005 Mar;90(3):1613-7. Epub 2004 Dec 7.
Comparison of the Metabolic Effects of Raloxifene and Oral Estrogen in Postmenopausal and Growth Hormone-Deficient Women.J Clin Endocrinol Metab. 2005 Apr 26; [Epub ahead of print]
Serum insulin-like growth factor I levels in growth hormone-deficient adults: influence of sex steroids.Horm Res. 2004;62 Suppl 1:73-6.
Growth hormone enhances effects of endurance training on oxidative muscle metabolism in elderly women. Am J Physiol Endocrinol Metab, Nov 2000; 279: 989 - 996.
J Gerontol A Biol Sci Med Sci 1998 May;53(3):M183-7
Sunday, March 25, 2007
Primobolan
Primobolan
Primobolan is one of those anabolic steroids which has a cult following not unlike the old original version of Masteron. Actually, as you can easily see from it´s anabolic:androgenic ratio below in the profile, it´s a pretty weak steroid but actually stronger(!) than Masteron in both regards. I don´t know anyone who has run both compounds at the same dose. We are probably justified in speculating that you´d probably get similar results from either of them, when you consider the fact that you are getting quite a bit less actual drug and more ester when you choose injectable Primobolan (which has the very long Enanthate ester attached to it) over Masteron (which has the very short propionate ester attached to it). In truth, I think part of the reason many Primobolan users have been disappointed is that they failed to use enough of it, for long enough. From it´s chemical structure and anabolic:androgenic rating, we can assume it is at least as effective as Masteron, on an equal Mg for mg basis. However, due to its ester (in the injectable version), it needs to be run for at least 12 weeks to see the full benefits from it. When you consider a measly dose of 400mgs of
this stuff for 12 weeks will probably cost you around $500.
Primobolan is one of those anabolic steroids which has a cult following not unlike the old original version of Masteron. Actually, as you can easily see from it´s anabolic:androgenic ratio below in the profile, it´s a pretty weak steroid but actually stronger(!) than Masteron in both regards. I don´t know anyone who has run both compounds at the same dose. We are probably justified in speculating that you´d probably get similar results from either of them, when you consider the fact that you are getting quite a bit less actual drug and more ester when you choose injectable Primobolan (which has the very long Enanthate ester attached to it) over Masteron (which has the very short propionate ester attached to it). In truth, I think part of the reason many Primobolan users have been disappointed is that they failed to use enough of it, for long enough. From it´s chemical structure and anabolic:androgenic rating, we can assume it is at least as effective as Masteron, on an equal Mg for mg basis. However, due to its ester (in the injectable version), it needs to be run for at least 12 weeks to see the full benefits from it. When you consider a measly dose of 400mgs of
this stuff for 12 weeks will probably cost you around $500.
It´s easy to see why many people have tried to use less...and have been disappointed with their results. On the other hand, many competitive bodybuilders consider Primobolan indespensible to their pre-contest drud routine, and wouldn´t consider dieting without it. Anyway...I think the comparison to Masteron (another great precontest drug) is the best one we can make, with reference to expected gains and results.
I happen to be one of the few people who have used Drostanolone Enanthate (Masteron with the Enanthate ester attached) as well as Methenolone Enanthate (injectable Primobolan). I can tell you that the results from these two compounds, when ester and mg potency are the same, are in fact very similar.
Effects of Primobolan
Let´s flesh out some of the various general effects of Primobolan, before we get into the differences between the oral and injectable versions... One study performed on sheep involved administering 100mgs of Methenolone, and electronically stimulating their lats (electronic stimulation was used because they kept falling off the chin-up bars). Anyway, when compared with the lat muscles of sheep who didn´t receive Methenolone, the receiving group gained significantly more muscle mass as well as strength (1)(2). It´s also has a relatively high affinity for binding to the AR, actually binding better than testosterone (3). This ability to strongly bind to the AR may be why Primobolan is such a good "fat burner." Strong AR binding has been positively correlated with lypolysis (fat-burning) (8).
In addition, as this steroid can actually aid in reducing breast tumors, no ancillary products need be considered for use with Primobolan, and in fact, it may actually be a useful ancillary agent in it´s own right, similar to Masteron. Also, just like Masteron, Primobolan has no propensity to aromatize (convert to estrogen). Since it doesn´t aromatize, alot of the side effects commonly associated with estrogen will not be of concern. This means water retention, acne, and gyno will be non-existent more or less. this lack of water retention combined with the slow and steady gains provided by Primo may help to explain why it has earned a reputation for creating quality muscle gains. This also helps to explain why it is so expensive. Although estrogenic sides are not a concern, hair loss still, remains a very real concern with Primobolan, as with many DHT-Derived steroids. Many primobolan fans always include Finasteride and Ketoconazole (shampoo) in cycles containing Primobolan.
Although nobody would ever suggest to use Primobolan as a bulking agent, it´s been studied as an agent to halt wasting and possibly reverse many of the adverse effects of anemia. It is a shocking failure in both areas, according to some of the case studies I´ve read, (5)(6) and this should come to no surprise to anyone. Anadrol reigns supreme in this area, and nobody in the athletic community would ever compare those two drugs. However, Michael Mooney and many other respected doctors who work with AIDS patients have found sufficient evidence to claim that Primobolan is an immune enhancer and as such is very useful for AIDS patients (not that the FDA cares...Primobolan is still not approved for sale in the United States). AIDS patients aren´t really in need of Bulking Drugs, so an immune enhancer like Primo which will add small, quality gains in muscle is perfect for them. And since we aren´t even going to vaguely consider the use of Primobolan as a bulking agent, clearly this leaves us with considering it primarily for use in gaining and maintaining lean tissue. It´s a great choice for this purpose, and many competitors have used it very successfully to retain muscle while on a calorie reduced diet. The reason Primo is so useful for this purpose is that one of its primary functions is to help your body retain nitrogen (7) at a greatly enhanced rate. The greater your nitrogen retention is, the more muscle you will build. In the case of using primo as a pre-contest drug, this nitrogen retention will help you retain muscle and ensure that your dieting preferentially favors fat loss over muscle loss.
Primobolan is a very unique steroid, as it is one of the few that comes in both an oral as well as an injectable version. I suppose Winstrol does also, but Primobolan actually has a different ester on the oral (acetate ) and injectable (Enanthate) versions. The oral version is one of the more interesting oral compounds I´ve looked into. For starters, it´s one of the few compounds available to athletes and bodybuilders which is both oral as well as non-17-alpha-alkylation. This alteration is (as I´m sure you remember from other stuff I´ve written) what generally makes oral steroids survive their first pass through your liver, but also makes them Hepatoxic (Liver toxic). Well... oral Primo doesn´t have this feature, so it is very mild on your liver (actually it basically isn´t liver toxic at all), but also is largely destroyed by it, since 17 beta estrification and 1 alkylation is the method used to make this stuff orally available. You´ll need to take a lot of this stuff for it to be effective... 100mgs/day of the oral version is a safe estimate for reasonable gains& for women, you could get away with less; perhaps 25mgs/day. Even though the acetate ester has a 2-3 day active life, your liver will do some damage to oral primo, so every day dosing will still be necessary.
When men were given a 30-45mg dose of the oral version of Primo, they experienced a 15-65% decrease in gonadotropin levels (9). Remember, I said 100mgs is a good dose for gains... well, you´ll also reduce your gonadotropin levels considerably. I have personally never understood why people recommend either oral or injectable Primobolan as a possible bridging compound for this reason... maybe at a too-low-to-do-anything dose of 10mgs it could be used as a bridge. And forget about using injectable Primo to bridge&
Hey... speaking about injectable Primo...
I´ve used this stuff at 200mgs/week and wasn´t very impressed with it. Generally, I think injectable primo needs to be used at a dose of at least 350mgs/week (100mgs/Every other Day), and preferably at a dose of 400-600mgs/week. I happen to like running it with testosterone propionate, but for convenience I would imagine most people would run it with Testosterone Enanthate, to keep dosing times the same (shooting it twice per week, in most cases).
Buying Primobolan
The unfortunate truth about injectable Primo is that it´s a very expensive chemical to obtain, and that price is reflected in the cost to the average consumer. Ten dollars per 1ml/100mg ampule is not unheard of, and I´ve seen it go for more. This is, of course, absurd. As if that´s not enough, this is also the most commonly counterfeited steroids on the black market. I recommend buying Primobolan (either the oral or injectable) from a respected Underground lab instead of trying to play a game of "spot the fake steroid" in Mexico or Europe. The underground versions should cost between $5-7 for 100mgs of Methenolone and I wouldn´t really consider paying more for it, although I have seen the British Dragon version of this product priced up to $20/ml.
Primobolan Profile
(Methenolone) (Oral Version is + Acetate Ester) (Injectable Version is + Enanthate Ester) [17beta-Hydroxy-1-methyl-5alpha-androst-1-en-3-one] Molecular weight of base: 302.4558 Molecular weight of Acetate ester: 60.0524 Molecular weight of Enanthate ester: 130.1864 Formula: C20H30O2 Melting Point: Manufacturer: Schering Effective dose(oral): (Men)50-100mgs/day; (Women) 10-25mgs/day Effective dose (injectable): (Men) 350-600mgs/week; (Women) 100mgs/week Active Life: 10-14 days (injectable); 4-6hrs (oral) Detection Time: 4-5 weeks Anabolic/Androgenic Ratio (Range): 88:44-57
Thursday, March 22, 2007
Nolva vs. Clomid for PCT
Nolva vs. Clomid for PCT
It seems like everyday questions concerning PCT pop up, and weather one should use either Clomid or nolva or a combo of both. I hope that this article written by BigCat may help to clear up some misconceptions.
While practically similar compounds in structure, few people ever really consider Clomid and nolva to be similar. Its not just a common myth in steroid circles, but even in the medical community. This misconception originates from their completely different uses. Nolvadex is most commonly used for the treatment of breast cancer in women, while Clomid is generally considered a fertility aid. In bodybuilding circles, from day one, Clomid has generally been used as post-cycle therapy and Nolvadex as an anti-estrogen.
But as I intend to demonstrate this is in essence the same. I believe the myth to have originated because nolva is clearly a more powerful anti-estrogen, and the people selling Clomid needed another angle to sell the stuff, so it was mostly used as a post-cycle aid. But few users really understand how Clomid (and also Nolvadex, logically) works to bring back natural testosterone in the body after the conclusion of a cycle of androgenic anabolic steroids. After a cycle is over, the level of androgens in the body drop drastically. The body compensates with an overproduction of estrogen to keep steroid levels up. Estrogen as well inhibits the production of natural testosterone, and in the period between the return of natural testosterone and the end of a cycle, a lot of mass is lost. So its in everybody's best interest to bring back natural test as soon as humanly possible. Clomid and Nolvadex will reduce the post-cycle estrogen, so that a steroid deficiency is constated and the hypothalamus is stimulated to regenerate natural testosterone production in the body. That's basically how the mechanism works, nothing more, nothing less.
Both compounds are structurally alike, classified as triphenylethylenes. Nolvadex is clearly the stronger component of the two as it can achieve better results in decreasing overall estrogen with 20-40 mg a day, than Clomid can in doses of 100-150 mg a day. A noteworthy difference. Triphenylethylenes are very mild estrogens that do not exert a lot, if any activity at the estrogen receptor, but are still highly attracted to it. As such they will occupy the receptor and keep it from binding estrogens. This means they do not actively work to reduce estrogen in the body like Proviron, Viratase or arimidex would (by competing for the aromatase enzyme), but that it blocks the receptor so that any estrogen in the body is basically inert, because it has no receptor to bind to.
This has advantages and disadvantages. The disadvantage is that when use is discontinued, the estrogen level is still the same and new problems will develop much sooner. The advantage is that it works much faster and has results sooner than with an aromatase blocker like Proviron or arimidex. Therefor, when problems such as gynocomastia occur during a cycle of steroids one will usually start 20 mg/day of nolva or 100 mg/day of Clomid straight away, in conjunction with some Proviron or arimidex. The proviron or arimidex will actively reduce estrogen while the Clomid or Nolvadex will solve your ongoing problem straight away. This way, when use is discontinued there is no immediate rebound.
So which one should you use? Well personally, I'd have to say Nolvadex. Both as an on-cycle anti-estrogen and a post-cycle therapy. As an anti-estrogen its simply much stronger, demonstrated by the fact that better results are obtained with 20-40 mg than with 100-150 mg of Clomid. For post-cycle, this plays a key role as well. It deactivates rebound estrogen much faster and more effective. But most importantly, Nolvadex has a direct influence on bringing back natural testosterone, where as Clomid may actually have a slight negative influence. The reason being that tamoxifen (as in Nolvadex) seems to increase the responsiveness of LH (luteinizing hormone) to GnRH (gonadtropin releasing hormone), whereas Clomid seems to decrease the responsiveness a bit1.
Another noteworthy fact about Nolvadex is that it acts more potently as an estrogen in the liver. As you remember, I mentioned that clomiphene and tamoxifen are basically weak estrogens. Well, tamoxifen is apparently still quite potent in the liver. This offers us the positive benefits of this hormone in the liver, while avoiding its negative effects elsewhere in the body. As such Nolvadex can have a very positive impact on negative cholesterol levels2 in the body, and therefore too should be considered a better choice than Clomid. It will not solve the problem of bad cholesterol levels during Steroid use, but will help to contain the problem to a larger degree.
Another reason why I promote the use of Nolvadex over Clomid post-cycle (as if being 3-4 times stronger and having more of a direct effect on restoring natural test wasn't enough) is because it's a lot safer. Not just because it improves lipid profiles, but also because it simply doesn't have the intrinsic side-effects that Clomid has. Clomid causes more acne for sure, but that's mainly because you need to use a 3-4 times higher dose. But Clomid seems to also affect the eyesight. Long-term Clomid therapy causes irreversible changes in eyesight3 in users. Irreversible. For me that alone is reason enough to prefer Nolvadex.
Lastly, one should be aware that use of these compounds can reduce the gains made on steroids. Nolvadex more so than Clomid, simply because it is stronger. Estrogen is responsible for a number of anabolic factors such as increasing growth hormone output, upgrading the androgen receptor and improving glucose utilization. This is why aromatizing steroids like testosterone are still best suited for maximum muscle gain. When reducing the estrogen levels, we therefore reduce the potential gains being made. For this reason one may opt to try Clomid during a cycle instead of Nolvadex. Although I would imagine that the problem that needed solved would be of more concern, in which case nolva remains the weapon of choice. It's a plain fact that there is a high correlation between gains and side-effects. Either you go for maximum gains and tolerate the side-effects, or you reduce the side-effects, and with it the gains. That's life, nothing is free.
Stacking and Use:
If problems of Gynocomastia or other estrogen related symptoms tend to pop up during a cycle the use of 20-30 mg of Nolvadex or 100 mg of Clomid daily should easily contain the problem, and be used until a few days after the problem subsides. For best results and the least amount of problems upon cessation it is best stacked with proviron (50 mg) or arimidex (0.5 mg) for this duration as well. Its not advised that these products be ran concomitantly with the steroid for the entire duration of the stack, as this will reduce your gains. Instead cease the usage of anti-estrogens once the problem is contained, and should the problem resurface, simply recommence the use of the products in the same manner as described above.
Once a cycle of steroids is concluded one should always initiate a post-cycle therapy to help bring back natural testosterone as soon as possible. This will help you to retain the mass you gained. How this is done depends highly on the type of steroid used. If only orals were used, therapy should start immediately, even the last day of the stack. If short-acting esters or water-based injectables were used, therapy should commence within 4-7 days after last injection, and if long-acting esters were used then it should commence 1.5 to 2 weeks after the last injection was given. The length of the therapy will vary as well, from 3-5 weeks. The longer acting the product was, the longer therapy should be continued to make sure all suppressive factors are cleared before use of Clomid/Nolvadex is discontinued.
The questions you will hear from athletes over and over is if they can get legal steroids clomid and nolvadex, is it possible?well I say yes you just have to look.
For best results, it is best stacked with HCG (Human Chorionic gonadotrophin), which functions as an LH analog and can help bring testicle size back up. HCG use starts the last week of a cycle, and on from there every 5-6 days (usually 1500-3000 IU) and discontinued 1.5 to weeks prior to the cessation of Nolvadex/clomid. The reason being that HCG itself is also suppressive of natural testosterone and should be out of the body before therapy is over, or it will inhibit natural testicle function. But I can not stress enough that HCG possibly plays a more important role in post-cycle therapy than clomid/Nolvadex. For Clomid and Nolvadex, doses are usually tapered down. Its best to start with 40-50 mg of Nolvadex or 150 mg of Clomid for the first week or the first two weeks, and then finish the program with 20-25 mg of Nolvadex or 100 mg of Clomid for an additional two weeks.
References
1 Vermeulen A., Comhaire F., Hormonal effects of an anti-estrogen, tamoxifen, in normal and oligospermic men, Fertil. Ster. 29 (1978) 320-27
2 Bruning PF, Bronfer JMG, Hart AAM, Jong-Bakker M, tamoxifen, serum lipoproteins and cardiovascular risk, Br. J. Cancer 1988 Oct, 58 (4) 497-9
Sunday, March 18, 2007
Anabolic Workout Guide
You should take the following factors to heart since they are absolutely necessary for a successful training. What role does the use of anabolic/androgenic steroids play- Very simple: athletes who take steroids will make clearly faster, better, and greater progress than their natural colleagues. They will also obtain a much higher development stage than would have ever been possible without taking pharmaceutical compounds. Such stupid statements that one will achieve the same mass as a bodybuilder without taking steroids -it only takes longer- is nothing but a completely absurd publicity by the authorities who in their own interest conceal the truth. Read the following lines with an open-minded attitude and try to adapt this information for your own needs. 1. High-intensity training: The human organism vehemently refuses any unnecessary change since it feels best in a constant condition, a homeostasis. In order to lure it out of its passivity, several efforts and exertions must be made. The signal that the body needs in order to build up strength and muscle mass is triggered by heavy, hard, and intense training routines. These should consist of relatively few sets. Five to eight sets for large muscle groups and three to four sets for small muscle groups are completely sufficient when every set is carried out until muscle failure. 2. Training with relatively low repetitions: The body has two different types of muscle fibers: Since the muscle hypertrophy almost completely occurs in the fast-twitch white muscle fibers of type 2, a sensible bodybuilding workout must be developed in a way that these are sufficiently stimulated. For this purpose relatively few, heavy reps in the range of 6-10 are suitable. 3. Training with progressively heavier weights: In order to build up massive muscles they must be challenged and exposed to regular progressively-higher resistances. This can be achieved when the athlete continuously increases the weight during exercises. The stronger the muscles the larger their appearance. There is no mass without power. The basic exercises such as squats, bench presses, presses behind the neck, rows, barbell curls, dips, etc. are the most suitable. 4. Sufficient rest periods: The muscles are stimulated through training but only grow during their rest phase. The higher the intensity, the higher the damage of the muscle cell and the longer the resting phase. When you train with adequate intensity you simply cannot train each and every day nor should you attack a muscle twice a week. Learn to accept rest and recovery as important factors of your training success. Every day you train in the GYM should be followed by a complete off day. Bodybuilders who are interested in an optimal strength and muscle gain should train every muscle once very intensely every 7-8 days. 5. Plateau and phase training: The body can be put under maximum stress only for a limited time. If this time is exceeded, development comes to a stop and if continued the performance will regress. For this reason the intensity and extent of the training program should be changed every 12-14 weeks. The athlete should enjoy several days off training and then change to a several-week long maintenance training (plateau training). The following training program considers all essential factors which are necessary for a quick buildup of strength and muscle mass. In combination with the nutrition tips included in this book its effectiveness can be considerably increased. Based on the high intensity it is not suitable for natural bodybuilders over a long time. This training schedule is obviously only intended as a suggestion and can be changed by every athlete to meet his individual needs, as long as the discussed principles are met. Eight-Day Training Cycle: One day training, one day rest(One day on, one day off)Day 1: Chest, biceps Bench presses 3 sets 6- 8 reps Incline bench presses 2 sets 6- 8 reps Dips with added weights 2 sets 8-10 reps Barbell curls 3 sets 6-10 reps Dumbbell curls 2 sets 6-10 reps Day 3: Thighs Squats 3 sets 6-10 reps Leg presses 2 sets 8-10 reps Leg curls 2 sets 8-10 reps Day 5: Shoulder, triceps Presses behind neck 3 sets 6- 8 reps Upright row 2 sets 8-10 reps Side laterals 2 sets 8-10 reps Lying triceps presses 3 sets 6-10 reps Triceps pulley pushdown 2 sets 8-10 reps Day 7: Back. calves Chins with added weight 3 sets 8-10 reps Lat pull to neck 2 sets 8-10 reps Barbell bent-over row 2 sets 6-10 reps Seated cable row 2 sets 6-10 reps Standing calf raise 3 sets 8-12 reps Seated calf raise 2 sets 8-12 reps Note: Training is only on uneven days, i.e. every 2nd, 4th, 6th, and 8th day is a complete rest day. The intervals between the various sets should be 3-4 minutes. The athlete should pay attention that the exercises -as much as possible- are carried out with free weights and not on machines. Every muscle is directly trained only once every eight days. It is important that every set is carried out until muscle failure meaning that the athlete is unable to do another rep-etition on its own. Only in this case are the relatively few sets and especially long rest periods justified. The muscle cell must be brought in a strongly catabolic condition since only then the distinct anticatabolic effect of anabolic/androgenic steroids develops fully. The required intensity of training, however, can only be achieved when you start (after a short warmup) with the heaviest weight possible and then decrease the weight in every following set because of the losing body strength so that the desired repetitions can still be obtained. In order to avoid any misunderstandings we would like to quickly explain this principle on an example. Our athlete is able to carry out a maximum of six repetitions with 300 pounds on bench presses. 1st warmup set: 10 reps with 140 pounds 2nd warmup set: 2 reps with 200 pounds 3rd warmup set: 2 reps with 240 pounds 1st working set: 6 reps with 300 pounds 2nd working set: 7 reps with 280 pounds 3rd working set: 7 reps with 260 pounds The first warmup set serves to bring blood to the muscles and joints. The second and third warmup set are an approach to the weight of the first working set. The interplay between the muscle and nerve is stimulated, meaning the athlete gets a feeling for the heavy weights without wasting strength and energy at the same time. During the following chest exercises the warmup sets are completely omitted which means that they are only necessary for the first exercise of the muscle to be trained. Do not forget, however, that during every exercise or set you should try to squeeze out an additional one or two repetitions than during the previous training in order to in-crease training weights in the following week. This continuous tire-some struggle to increase repetitions and weight is the only way to a massive body. Always remember: HEAVY WEIGHTS BUILD BIG MUSCLES. http://www.isteroids.com/
Friday, March 16, 2007
Clomid® (clomiphene citrate)
Clomid® (clomiphene citrate)
Quick overview:
Active Life: 5-7 daysDrug Class: Selective Estrogen Receptor Modulator (Oral)Average Dose: Men 50-100 mg/dayAcne: YesWater Retention: NoHigh Blood Pressure: RareLiver Toxic: LowAromatization: NoneDecrease HPTA function: No, used to restore itStrong gonadotropin stimulator/mild anti-estrogen
Clomid® is the commonly referenced brand name for the drug clomiphene citrate. It is not an anabolic steroid, but a prescription drug generally prescribed to women as a fertility aid. This is due to the fact that clomiphene citrate shows a pronounced ability to stimulate ovulation. This is accomplished by blocking/minimizing the effects of estrogen in the body. To be more specific Clomid is chemically a synthetic estrogen with both agonist/antagonist properties, and is very similar in structure and action to Nolvadex. In certain target tissues it can block the ability of estrogen to bind with its corresponding receptor. Its clinical use is therefore to oppose the negative feedback of estrogens on the hypothalamic-pituitary-ovarian axis, which enhances the release of LH and FSH. This of course can help to induce ovulation.
For athletic purposes, Clomid does not offer a tremendous benefit to women. In men however, the elevation in both follicle stimulating hormone and (primarily) luteinizing hormone will cause natural testosterone production to increase. This effect is especially beneficial to the athlete at the conclusion of a steroid cycle when endogenous testosterone levels are depressed. If endogenous testosterone levels are not brought beck to normal, a dramatic loss in size and strength is likely to occur once the anabolics have been removed. This is due to the fact that without testosterone (or other androgens), the catabolic hormone cortisol becomes the dominant force affecting muscle protein synthesis (quickly bringing about a catabolic metabolism). Often referred to as the post-steroid crash, it can quickly eat up much of your newly acquired muscle. Clomid can play a crucial role in preventing this crash in athletic performance. As for women, the only real use for Clomid is the possible management of endogenous estrogen levels near contest time. This can increase fat loss and muscularity, particularly in female trouble areas such as this hips and thighs. Clomid however often produces troubling side effects in women (discussed below), and is likewise not in very high demand among this group of athletes.
Male users generally find that a daily intake of 50-100 mg (1-2 tablets) over a four to six week period will bring testosterone production back to an acceptable level. A very common regime of dosing is; 300 md/day 1, 100 mg/day for days 2-11, and 50 mg/day for days 12-21. This raise in testosterone should occur slowly but evenly throughout the period of intake. Since an immediate boost in testosterone is often desirable, many prefer to combine Clomid with HCG (Human Chorionic Gonadotropin) for the first week or two after the steroids have been removed. The kick-start from HCG also helps to restore the normal ability for the testes to respond to endogenous LH, which may be hindered for some time after the cycle is ended due to a prolonged state of inactivity. Once the HCG is stopped, the user continues treatment with Clomid alone. HCG should not be used for longer than two or three weeks though, as the resulting increased testosterone and estrogen levels may again initiate negative feedback inhibition at the hypothalamus. When planning your ancillary drug program, it is also important to remember that injectable steroids can stay active for a long duration. Using ancillary drugs the first week after a long acting injectable like Sustanon has been stopped may prove to be wholly ineffective. Instead, the athlete should wait for two to three weeks, to a point where androgen levels will be diminishing. Here the body will be primed and ready to restore testosterone production.
Clomid and HCG are also occasionally used periodically during a steroid cycle, in an effort to prevent natural testosterone levels from diminishing. In many instances this practice can prove difficult however, especially when using strong androgens for longer periods of time. There is also no exact method for using the two drugs in this manner. Some have experimented by periodically administering small doses of HCG along with one or two tablets of Clomid, perhaps for a few days at a stretch followed by a longer break. An on/off schedule would be implemented; for fear that this combination may lose some effectiveness if used continuously for this purpose. This method of intake may prove to be effective, although it is really much more feasible to stimulate testosterone production after the cycle than to try and maintain it for the long duration during.
In addition to helping with the post-cycle testosterone crash, this drug can also help with elevated estrogen levels during a steroid cycle. A high estrogen bevel puts an athlete in serious risk of developing gynecomastia, which is an obvious unwanted side effect. With the intake of Clomid, the athlete can hopefully reduce his risk for developing gynecomastia. The estrogen "blocking" properties of Clomid appear to be slightly weaker than Nolvadex in comparison however, which is why it is not usually thought of as an equal substitute for estrogen maintenance. Of course both drugs have similar actions in the body. and are relatively interchangeable for this purpose. Clomid can likewise also be used as a maintenance anti-estrogen throughout the duration of steroid cycle with good confidence, just as is done with Nolvadex. In most instances this will prove equally sufficient, the drug effectively minimizing the activity of estrogen in the body and warding off gyno and excess water/fat retention. Unfortunately just as with Nolvadex this is not always the case however, and many find it necessary to addition another anti-estrogenic drug. The most common adjunct is Proviron, an oral DHT used to competitively lower aromatase activity and raise the androgen to estrogen ratio. The Clomid/Nolvadex and Proviron combination is extremely effective, although we could alternately replace them both with a more specific aromatase inhibitor such as Arimidex,Femara, or Aromasin. While stronger at combating estrogen in most cases, these drugs are also typically much more costly.
As for toxicity and side effects, Clomid is considered a very safe drug. Bodybuilders seldom report any problems, but listed possible side effects do include hot flashes, nausea, dizziness, headaches and temporarily blurred vision. Such side effects usually only appear in females however, as they feel the effects of estrogen manipulation much more readily than men. While female athletes can clearly gain some benefit from this substance, estrogen manipulation is probably not the most comfortable way to go about cutting up. Should it still be used for such purposed and side effects do become pronounced, the drug of course is to be discontinued and (at least) a break taken from it.
Clomiphene citrate is widely available on the black market in a variety of brand names as well as generic tabs and liquid versions.
Tuesday, March 13, 2007
Proviron
Proviron
Mesterolone Proviron (mesterolone) is basically an orally active DHT (Dihydrotestosterone) preparation. For comparision, we can think of some other orally prepared DHT compounds like Winstrol, Anavar, etc& Those both act very similarly in mechanism to Proviron, but a more accurate way to think of this compound is as something like "Oral Masteron." As I´m sure you noticed, their anabolic/androgenic ratio is very similar.Remember, DHT is 3 to 4 times as androgenic as testosterone and is, of course, incapable of forming estrogen. Also, Proviron is 
quite unique in that a simple look at it´s 4-ring structure will show us that it is not going to be too liver toxic, since it is not c17-Alpha-Alkylated, as many orals are& this modification (lacking in Proviron) makes drugs more liver toxic. Proviron has a 1-metyhl group added, instead. Looks pretty great on paper, right? Well, as usual, things tend to look better on paper than they do in the body. Your body has a negative feedback loop which prevents your body from having too much DHT floating around(if you´ve been paying attention up to now from reading my other stuff, you already know this). An excess of DHT will eventually be changed into another (largely not anabolic) compound.
And of course, being a DHT-based compound, this stuff isn´t going to be great for female athletes to use. Virilization (development of male sexual characteristics) is going to be a concern for women daring enough to try this stuff. My advice is that there is much better, safer compounds for female athletes and bodybuilders to use.
So lets go back to the comparison with being some sort of "Oral Masteron"& basically since Proviron is 5-alpha reduced and not capable of forming estrogen, and also has a very high affinity for binding to the aromatase enzyme (the enzyme responsible for converting all that good testosterone in your body into all that nasty estrogen). That means if you choose to take proviron with testosterone (and I know you wouldn´t even be doing a cycle without including some form of testosterone) and/or any aromatizable steroid, it should actually serve to prevent estrogen build up by the aforementioned binding to the aromatase enzyme, which prevents aromatase from doing it´s dirty work and making a bunch of estrogen out of the other steroids you are taking. It should also be noted that Proviron also binds very well to SHBG (Sex Hormone Binding Globulin& a hormone responsible for reducing the amount of circulating free testosterone in your body)(1). As a matter of fact, in the last study I read, it bound to SHBG better than any other drug studied. Also, I´d like to note that Proviron bound to the Anabolic Receptor better than any oral anabolic (except for the insanely toxic MethylTrienolone), having an ability to bind to the AR better then testosterone, but not as well as Nandrolone (1). Unfortunately, as we know, DHT also has a high affinity for binding to receptors in the scalp and prostate, causing some possible nasty side effects, like male pattern baldness and prostate enlargement. It´s important to remember that DHT and DHT derived compounds are used quite successfully to treat gynocomastia, and in this area, Proviron is no different.
Let´s delve into some of the positive points of this drug before we go any farther. Androgen Receptors are found in fat cells as well as muscle cells(5), and whilethey act on the AR in muscle cells to promote growth, they also act directly on the AR in fat cells to affect fat burning.(9)(3) The stronger the androgen binds to the A.R, the higher the lipolytic (fat burning) effect on adipose (fat)tissue(6)(2). As if that´s not enough good news, some steroids (notably, testosterone) even increase the numbers of A.R. in muscle and fat (9)(7). Thus, if you are taking a simple stack of proviron and testosterone, you´ll have more of the test you shoot as free testosterone floating around building muscle (compliments of the Proviron), more androgen receptors to be bound to (compliments of your testosterone) by your Proviron, thus causing more fat loss. Testosterone and Proviron are a very nice synergistic stack, pretty nearly an "ideal" stack of an oral and injectable, because both drugs will actually act to enhance the effect of the other.
So what we have here is a steroid which can basically make other steroids more effective by preventing their conversion into estrogen, as well as increasing the amount of circulating free testosterone in your body. This of course all provides a more hardened and quality look to muscles. Proviron is very much a "synergistic" drug in this respect, and it´s inclusion in any cycle would definitely make all of the other steroids perform better, and provide better gains. This is all compounded by the fact that proviron is a very lipolytic (fat-burning) drug.
Now, as if all of this weren´t enough, let´s talk about how Proviron affects your HPTA (Hypothalamic-Pituitary-Testicular-Axis)& the thing that regulates the male hormonal system. When a reasonable dose of this stuff is given (100-150mgs/day), it had no depressing effect on low or normal serum FSH and LH levels (6). Follicle Stimulating Hormone (FSH) and Leutenizing Hormone (LH) are two hormones which send a signal to your testes to produce testosterone. Good news for people considering it for PCT is that it can even raise your LH (10)! Thus, by not suppressing those hormones and maybe even raising some, your normal testosterone levels will remain intact. This points to a novel use for this compound during Post-Cycyle-Therapy for a non-suppressive "bridge" between cycles. In fact, in yet another study, administration of Proviron (basically the same dose as in the last study) produced no changes in steroids, thyroid hormones, gonadotropins nor PRL (Prolactin Levels& you want those to remain low). (8).
Unfortunately, this stuff is not too hot on it´s own. It´s a good drug for inclusion in a cycle containing testosterone and other armoatizable steroids, and it´s a good drug for a possible "bridge" between cycles. Alone, however, as an androgenic or anabolic agent, it´s effects have been very weak in both studies (9), as well as in the experience of everyone I spoke to about it. This may be due to the addition of the 1-methyl-group to DHT, which makes this stuff orally active. Whatever the case, as a stand alone anabolic or androgenic compound, it´s not too impressive.
This drug is a rare find on the American Black Market, and many Underground Labs don´t even produce it, but if you can find it, I´d say that you shouldn´t be paying more than .50cents for each 50mg tab.
Proviron (Mesterolone) Profile
[1 alpha-methyl-17 beta-hydroxy-5 alpha-androstan-3-one] Molecular Weight: 304.4716 Molecular Formula: C20H32O2 Melting Point: N/A Manufacturer: Schering Release Date: 1960 Effective Dose: 25-200mgs/day Active Life: up to 12 hours Detection Time: 5-6weeks Androgenic: Anabolic Ratio:30-40/100-150
Saturday, March 10, 2007
Primobolan® Tablets (methenolone acetate)
Primobolan® Tablets (methenolone acetate)
Quick overview:
Active Life: 4-6 hours
Drug Class: Anabolic/Androgenic Steroid (Oral)
Average Dose: Men 50-150 mg/day......Women 50-75 mg/day
Acne: Rare
Water Retention: No
High Blood Pressure: Rare
Liver Toxic: Very low and only in very high dosages
Aromatization: None
DHT Conversion: No
Decrease HPTA function: Low
Comments: Moderately Anabolic/Low Androgenic
This section refers to the oral Primobolan® preparation, which contains the drug methenolone acetate. It is very similar in action to the injectable Primobolan® Depot (methenolone enanthate), but obviously here the drug is designed for oral administration. At one time Schering was in fact also manufacturing an injectable methenolone acetate (Primobolan® acetate, out of manufacture since 1993), which proved to be very useful for pre-contest cutting purposes. This steroid is now gravely missed, as it was once a favorite among European competitors. Although we still have the acetate in oral form, it is a close, but not equal substitute (injection is a much more efficient form of delivery for this steroid).
Methenolone regardless of the ester is a very mild anabolic steroid. The androgenic activity of this compound is considerably low, as are its anabolic properties. One should not expect to achieve great gains in muscle mass with this drug. Instead, Primobolan® is utilized when the athlete has a specific need for a mild anabolic agent, most notably in cutting phases of training. It is also a drug of choice when side effects are a concern. A welcome factor is that Primobolan® is not c17 alpha alkylated as most oral steroid are. Due to the absence of such an alteration, this compound is one of the few commercially produced oral steroids that is not notably stressful to the liver. While liver enzymes values have been affected by this drug in some rare instances, actual damage due to use of this substance is not a documented problem. Unfortunately the 1 alkylation and 17-beta esterification of Primobolan® do not protect the compound very well during first pass however, so much of your initial dose will not make circulation. This is obviously why we need such high daily dose with the oral version of Primobolan®.
Primobolan® will also not aromatize, so estrogen related side effects are of no concern. This is very useful when leading up to a bodybuilding contest, as subcutaneous water retention (due to estrogen) can seriously lessen the look of hardness and definition to the muscles. Non-aromatizing steroids are therefore indispensable to the competitor, helping to bring about a tight, solid build the weeks leading up to a show. And of course without excess estrogen there is little chance of the athlete developing gynecomastia. Likewise there should never be a need for anti-estrogen use with this steroid. Primobolan® is also said to have a low impact on endogenous testosterone production. Although this may well be true in small clinical doses, it will not hold true for the bodybuilder. For example, in one study more than half of the patients receiving only 30-45 mg noted a suppression of gonadotropin levels of 15% to 65% a. This is a dose far less than most bodybuilders would use, and no doubt increasing it would only lead to worse suppression. One would therefore still need a testosterone stimulating drug like HCG or Clomid®/Nolvadex® when concluding a low-dose Primobolan® cycle, unless a deliberately small dose were being used.
It is also important to note that although the androgenic component of Primobolan® is low, side effects are still possible. One may therefore notice oily skin, acne and facial/body hair growth during treatment. Men with a predisposition for hair loss may also find it exacerbates this condition, and wish to avoid this item (nandrolone injectables are a much better choice). While always possible, side effects rarely reach a point where they interfere with the progress of cycle. Primobolan® is clearly one of the milder and safer oral steroids in production. Female athletes, older or more sensitive individuals and steroid beginners will no doubt find this a comfortable steroid to experiment with.
The dosage for men is somewhere in the range of 75-150mg daily. This can obviously be tedious (and costly) if one can only obtain the 5mg tablets from Mexico and S. America. A mild anabolic such as Primobolan® is often used in conjunction with other steroids for optimal effect, so some users find a slightly lower dose effective when stacking. During a dieting or cutting phase, thought to be its primary application, a non-aromatizing androgen like Halotestin® or trenbolone can be added for example. Such combinations would enhance the physique without water retention, and help bring out a harder and more defined look of muscularity. Non-aromatizing androgen/anabolic stacks like this are in fact very popular among competing bodybuilders. This compound is also occasionally used with more potent androgens during bulking phases of training. The addition of testosterone, Dianabol or Anadrol 50® would prove effective for instance, although the gains are likely to be accompanied by some level of smoothness due to the added estrogenic component.
Among women, Primobolan® is one of the most popular steroids in use. At a dosage of 50-75mg daily, virilization symptoms are extremely uncommon. One would of course not expect a tremendous amount of muscle mass with this drug, and instead should expect a slow and steady (quality) increase. Some women choose to further add-in other anabolics such as Winstrol® or oxandrolone, in an effort to increase the muscle building effectiveness of a cycle. While both of these compounds are quite tolerable to women, one must be sure not to use too high an accumulated dosage. Troublesome androgenic side effects are always a possibility with steroid use, even with very mild substances. Taken at too high a dosage, these weak anabolics can become a formidable danger to femininity. It would therefore be the best advice not to use the normal dosage range of both, but instead start with a much lower dosage of each steroid to compensate for the other. On the black market Primobolan® orals are popular, but still much less commonly found than the injectable. This is due to the higher cost effectiveness of the injectable, which uses the same active compound but with 100% bioavailability due to the form of administration.
Quick overview:
Active Life: 4-6 hours
Drug Class: Anabolic/Androgenic Steroid (Oral)
Average Dose: Men 50-150 mg/day......Women 50-75 mg/day
Acne: Rare
Water Retention: No
High Blood Pressure: Rare
Liver Toxic: Very low and only in very high dosagesAromatization: None
DHT Conversion: No
Decrease HPTA function: Low
Comments: Moderately Anabolic/Low Androgenic
This section refers to the oral Primobolan® preparation, which contains the drug methenolone acetate. It is very similar in action to the injectable Primobolan® Depot (methenolone enanthate), but obviously here the drug is designed for oral administration. At one time Schering was in fact also manufacturing an injectable methenolone acetate (Primobolan® acetate, out of manufacture since 1993), which proved to be very useful for pre-contest cutting purposes. This steroid is now gravely missed, as it was once a favorite among European competitors. Although we still have the acetate in oral form, it is a close, but not equal substitute (injection is a much more efficient form of delivery for this steroid).
Methenolone regardless of the ester is a very mild anabolic steroid. The androgenic activity of this compound is considerably low, as are its anabolic properties. One should not expect to achieve great gains in muscle mass with this drug. Instead, Primobolan® is utilized when the athlete has a specific need for a mild anabolic agent, most notably in cutting phases of training. It is also a drug of choice when side effects are a concern. A welcome factor is that Primobolan® is not c17 alpha alkylated as most oral steroid are. Due to the absence of such an alteration, this compound is one of the few commercially produced oral steroids that is not notably stressful to the liver. While liver enzymes values have been affected by this drug in some rare instances, actual damage due to use of this substance is not a documented problem. Unfortunately the 1 alkylation and 17-beta esterification of Primobolan® do not protect the compound very well during first pass however, so much of your initial dose will not make circulation. This is obviously why we need such high daily dose with the oral version of Primobolan®.
Primobolan® will also not aromatize, so estrogen related side effects are of no concern. This is very useful when leading up to a bodybuilding contest, as subcutaneous water retention (due to estrogen) can seriously lessen the look of hardness and definition to the muscles. Non-aromatizing steroids are therefore indispensable to the competitor, helping to bring about a tight, solid build the weeks leading up to a show. And of course without excess estrogen there is little chance of the athlete developing gynecomastia. Likewise there should never be a need for anti-estrogen use with this steroid. Primobolan® is also said to have a low impact on endogenous testosterone production. Although this may well be true in small clinical doses, it will not hold true for the bodybuilder. For example, in one study more than half of the patients receiving only 30-45 mg noted a suppression of gonadotropin levels of 15% to 65% a. This is a dose far less than most bodybuilders would use, and no doubt increasing it would only lead to worse suppression. One would therefore still need a testosterone stimulating drug like HCG or Clomid®/Nolvadex® when concluding a low-dose Primobolan® cycle, unless a deliberately small dose were being used.
It is also important to note that although the androgenic component of Primobolan® is low, side effects are still possible. One may therefore notice oily skin, acne and facial/body hair growth during treatment. Men with a predisposition for hair loss may also find it exacerbates this condition, and wish to avoid this item (nandrolone injectables are a much better choice). While always possible, side effects rarely reach a point where they interfere with the progress of cycle. Primobolan® is clearly one of the milder and safer oral steroids in production. Female athletes, older or more sensitive individuals and steroid beginners will no doubt find this a comfortable steroid to experiment with.
The dosage for men is somewhere in the range of 75-150mg daily. This can obviously be tedious (and costly) if one can only obtain the 5mg tablets from Mexico and S. America. A mild anabolic such as Primobolan® is often used in conjunction with other steroids for optimal effect, so some users find a slightly lower dose effective when stacking. During a dieting or cutting phase, thought to be its primary application, a non-aromatizing androgen like Halotestin® or trenbolone can be added for example. Such combinations would enhance the physique without water retention, and help bring out a harder and more defined look of muscularity. Non-aromatizing androgen/anabolic stacks like this are in fact very popular among competing bodybuilders. This compound is also occasionally used with more potent androgens during bulking phases of training. The addition of testosterone, Dianabol or Anadrol 50® would prove effective for instance, although the gains are likely to be accompanied by some level of smoothness due to the added estrogenic component.
Among women, Primobolan® is one of the most popular steroids in use. At a dosage of 50-75mg daily, virilization symptoms are extremely uncommon. One would of course not expect a tremendous amount of muscle mass with this drug, and instead should expect a slow and steady (quality) increase. Some women choose to further add-in other anabolics such as Winstrol® or oxandrolone, in an effort to increase the muscle building effectiveness of a cycle. While both of these compounds are quite tolerable to women, one must be sure not to use too high an accumulated dosage. Troublesome androgenic side effects are always a possibility with steroid use, even with very mild substances. Taken at too high a dosage, these weak anabolics can become a formidable danger to femininity. It would therefore be the best advice not to use the normal dosage range of both, but instead start with a much lower dosage of each steroid to compensate for the other. On the black market Primobolan® orals are popular, but still much less commonly found than the injectable. This is due to the higher cost effectiveness of the injectable, which uses the same active compound but with 100% bioavailability due to the form of administration.
Thursday, March 8, 2007
Testosterone Suspension
Testosterone Suspension
Testosterone suspension is simply testosterone crystals suspended in a sterile water solution. As such, it becomes active very quickly after injection, and agressiveness often sets in immediatel as well as a possible strength elevation. Since there is no ester, it also basically drops crystals into your muscle (painful), but it also gives you more bang for the buck than other forms of injectable testosterone.
As with all forms of testosterone, this product will convert to estrogen, cause some water
retention, possible acne and hairloss. Of course, testosterone will also build mass and strength faster than any other anabolic steroid as well, and should be the base of any cycle.
Reported Characteristics
Pharmaceutical Name:Testosterone
Chemical Name:4-androstene-3-one-17b-ol
Cutting/Bulking:Cutting
Anabolic Rating: 100
Active-Life: About one day.
Drug Class: Androgenic/Anabolic Steroid (For injection)
Average Reported Dosage: Men 150-1400mg weekly Women 25-50mg weekly
Acne: Yes, high
Water Retention: Yes, high
High blood Pressure: Often in higher dosages
Liver Toxic: Low
Aromatization: Yes, high
DHT Conversion: Yes-high
Decreases HPTA function: Yes
Average Price: $10/100mgs
Testosterone suspension is simply testosterone crystals suspended in a sterile water solution. As such, it becomes active very quickly after injection, and agressiveness often sets in immediatel as well as a possible strength elevation. Since there is no ester, it also basically drops crystals into your muscle (painful), but it also gives you more bang for the buck than other forms of injectable testosterone.
As with all forms of testosterone, this product will convert to estrogen, cause some water
retention, possible acne and hairloss. Of course, testosterone will also build mass and strength faster than any other anabolic steroid as well, and should be the base of any cycle.Reported Characteristics
Pharmaceutical Name:Testosterone
Chemical Name:4-androstene-3-one-17b-ol
Cutting/Bulking:Cutting
Anabolic Rating: 100
Active-Life: About one day.
Drug Class: Androgenic/Anabolic Steroid (For injection)
Average Reported Dosage: Men 150-1400mg weekly Women 25-50mg weekly
Acne: Yes, high
Water Retention: Yes, high
High blood Pressure: Often in higher dosages
Liver Toxic: Low
Aromatization: Yes, high
DHT Conversion: Yes-high
Decreases HPTA function: Yes
Average Price: $10/100mgs
Monday, March 5, 2007
Aromasin
Anabolic Steroids Profile Aromasin Exemestane Aromasin (Exemestane) is a steroidal suicide aromatase inhibitor, which means that it lowers estrogen production in the body by blocking the aromatase enzyme, the enzyme responsible for estrogen synthesization. (1)(2)(3) This stuff was developed to fight breast cancer in post-menopausal women, who need a particularly aggressive therapy, and for whom first line defenses such as SERMS (Tamoxifen) have not worked. This should be our first clue in inferring that this stuff is pretty strong, or at least stronger than some of the other compounds which are used to fight breast cancer. Aromasin and Side Effects Aromasin averages an 85% rate of estrogen suppression (4), so it´s clearly a very effective agent for bodybuilders and other athletes wanting to avoid estrogen related side effects such as gyno, acne, or water-retention brought on by aromatizing steroids. Specifically, Exemestane dose this by selectively inhibiting aromatase activity in a time-dependent and irreversible manner (hence the "suicidal" portion of it´s name, I guess).(7) As with most of the compounds in this class, it also causes a reasonable rise in testosterone levels (6), and as you may have guessed, this rise in testosterone means that Exemestane can also cause androgenic sides(8)(9)(10). As you can see from the chart below, exemestane is very effective at both lowering estrogen (estradiol) and raising testosterone: FIG. 1. Estrogen and androgen plasma levels after 10 d of daily exemestane (25 or 50 mg) in healthy young males (mean ± SD; n = 9-11). To convert to Systeme International units: estradiol, picomoles per liter (x3.671); estrone, picomoles per liter (x3.699); androstenedione, nanomoles per liter (*0.003492); and testosterone, nanomoles per liter (x0.03467). (13) So we can see that 25mgs is a very effective dose from that chart, right? As an added benefit, exemestane not only increases testosterone and lowers estrogen, but it also increases IGF levels (11).Additionally Worth noting is that Aromasin may possibly be less harsh on blood lipids (14)than some of the other (similar) compounds we use in the world of bodybuilding or athletics (other AI´s). It also has, at best no effect on IGF, and at worst could lower (13) it. AI´s are very tricky with regards to inconsistencies in IGF levels. Unfortunately, you need to take Exemestane for a week to reach steady blood plasma levels of it, and exemestane has a ½ life of 27 hours (12.). The ability of exemestane to lower estrogen levels by the aforementioned 85% makes it a very nice choice for use in any cycle where aromatizing steroids are used. In addition, since it´s not too harsh at all on blood lipid profiles, it´s a very good choice for longer cycles. It´s ability to raise both testosterone levels also seem to suggest that it would be a very nice addition to a Post-Cycle-Therapy (PCT).
Sunday, March 4, 2007
Fat Burning Secrets Of The Worlds Best Bodybuilders
Fat Burning Secrets Of The Worlds Best Bodybuilders
Outlaw Bodybuilder Thumbs Nose At Weight Loss "Experts" Who Earn Fortunes On The Sweat And Dreams Of Young Men & Women, And Finally Reveals The Simple Proven Science Of Fat Loss No One Else Will Tell You About...
Lifetime-Natural Bodybuilder, Personal Trainer, Nutritionist and Success Coach From New Jersey Teaches You How to Turbo-Charge Your Metabolism, Gain Muscle, Burn Off Body Fat and Develop Unstoppable Motivation ... Guaranteed! Discover How He's Taught Thousands of People to Get Leaner Faster Than They Ever Thought Possible!
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Who I Am And Why You Should Listen to Me
There are thousands of diet programs and dozens of people claiming to be experts. However, very few of these so-called "Fat loss experts" practice what they preach or have the credentials and track record to back up their claims. Since you're probably wondering how this program is different, here's the whole story:
I've been bodybuilding for 23 years and competing for 17 years. I've been involved in the fitness industry as a personal trainer, health club manager, nutritionist, motivation coach and freelance writer for nearly 18 years. Bodybuilding and fitness is my life - it's all I've ever done.
Outlaw Bodybuilder Thumbs Nose At Weight Loss "Experts" Who Earn Fortunes On The Sweat And Dreams Of Young Men & Women, And Finally Reveals The Simple Proven Science Of Fat Loss No One Else Will Tell You About...
Lifetime-Natural Bodybuilder, Personal Trainer, Nutritionist and Success Coach From New Jersey Teaches You How to Turbo-Charge Your Metabolism, Gain Muscle, Burn Off Body Fat and Develop Unstoppable Motivation ... Guaranteed! Discover How He's Taught Thousands of People to Get Leaner Faster Than They Ever Thought Possible!
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There are thousands of diet programs and dozens of people claiming to be experts. However, very few of these so-called "Fat loss experts" practice what they preach or have the credentials and track record to back up their claims. Since you're probably wondering how this program is different, here's the whole story:
I've been bodybuilding for 23 years and competing for 17 years. I've been involved in the fitness industry as a personal trainer, health club manager, nutritionist, motivation coach and freelance writer for nearly 18 years. Bodybuilding and fitness is my life - it's all I've ever done.
"Tom Venuto, in my opinion, is the leading, VERY BEST fitness expert and author of our time and much of my and our client's success are due to his teachings. He and his fat loss system are on the cutting edge of science and don't miss a nutritional tip, trick, secret, or strategy in achieving amazing results. What's more, they are offered in an easy-to-understand and easy-to-follow format.
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You may have seen my photos or articles in some of the magazines or on the Internet: I've been in IRONMAN, Muscular Development, Natural Bodybuilding & Fitness, Olympian's News (in Italian), Exercise for Men and Men's Exercise. I've written over 190 articles on bodybuilding, fat loss and fitness and you can find my articles featured on dozens of websites worldwide including Bodybuilding.com, Female Muscle.com, About.com, Lee Labrada's Lean Body Coaching Club, Will Brink's Muscle Building Nutrition.com, Global Health & Fitness.com, A to Z Fitness.com, and too many others to mention.
I have a BSc. degree in exercise science, I'm a certified strength and conditioning specialist (CSCS) and a certified personal trainer (NSCA-CPT). I'm a member of the International Society for Sports Nutrition (ISSN), the American College of Sports Medicine (ACSM) and the National Strength And Conditioning Association (NSCA). I'm a competitive bodybuilder and I've won three state and three regional championships. I've even gone as far as 2nd place in the Mr. Natural USA and 2nd in the Mr. Natural North America contests.
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Outlaw Bodybuilder Thumbs Nose At Weight Loss "Experts" Who Earn Fortunes On The Sweat And Dreams Of Young Men & Women, And Finally Reveals The Simple Proven Science Of Fat Loss No One Else Will Tell You About...
Lifetime-Natural Bodybuilder, Personal Trainer, Nutritionist and Success Coach From New Jersey Teaches You How to Turbo-Charge Your Metabolism, Gain Muscle, Burn Off Body Fat and Develop Unstoppable Motivation ... Guaranteed! Discover How He's Taught Thousands of People to Get Leaner Faster Than They Ever Thought Possible!
Even if You Have Less-than Average Genetics... Even If You've Never Succeeded at Losing Weight Before... Even If You Have Stubborn Fat Deposits That Don't Seem To Budge... Right Here on This Web Page You've Found The Fat Loss Success System You've Been Looking For!
If you would like to learn how to lose body fat permanently... even in your mushiest spots... without drugs, without supplements and without screwing up your metabolism, then this will be the most important web page you will ever read. I guarantee it and I've got the results to prove it!
Who I Am And Why You Should Listen to Me
There are thousands of diet programs and dozens of people claiming to be experts. However, very few of these so-called "Fat loss experts" practice what they preach or have the credentials and track record to back up their claims. Since you're probably wondering how this program is different, here's the whole story:
I've been bodybuilding for 23 years and competing for 17 years. I've been involved in the fitness industry as a personal trainer, health club manager, nutritionist, motivation coach and freelance writer for nearly 18 years. Bodybuilding and fitness is my life - it's all I've ever done.
Outlaw Bodybuilder Thumbs Nose At Weight Loss "Experts" Who Earn Fortunes On The Sweat And Dreams Of Young Men & Women, And Finally Reveals The Simple Proven Science Of Fat Loss No One Else Will Tell You About...
Lifetime-Natural Bodybuilder, Personal Trainer, Nutritionist and Success Coach From New Jersey Teaches You How to Turbo-Charge Your Metabolism, Gain Muscle, Burn Off Body Fat and Develop Unstoppable Motivation ... Guaranteed! Discover How He's Taught Thousands of People to Get Leaner Faster Than They Ever Thought Possible!
Even if You Have Less-than Average Genetics... Even If You've Never Succeeded at Losing Weight Before... Even If You Have Stubborn Fat Deposits That Don't Seem To Budge... Right Here on This Web Page You've Found The Fat Loss Success System You've Been Looking For!
Dear Friend,
You're about to discover what might be the most powerful fat loss system ever developed. It's the same diet program fitness models and bodybuilders use to reach single digit body fat levels and achieve rock-hard muscle definition that makes them look like walking anatomy charts.
My name is Tom Venuto and over the past 14 years, through a long and painstaking process of trial, error and experimentation, I've developed a sure-fire, 100% guaranteed system for losing body fat based on the little-known nutrition secrets of competitive natural bodybuilders and fitness models.
If you would like to learn how to lose body fat permanently... even in your mushiest spots... without drugs, without supplements and without screwing up your metabolism, then this will be the most important web page you will ever read. I guarantee it and I've got the results to prove it!
When I started Tom's Burn The Fat diet program in January, I weighed 317 pounds. As of Dec. 1st, I weigh 226 lbs. 91 pounds of fat gone forever is a pretty cool thing! And by the way... I turned 40 this year, so if anyone out there is thinking that you are "too old" - think again.
Chris Brooke, Marietta, GA
When I started the program in September, I was 248 pounds with 24% bodyfat. With Tom's information, I have been able to lose 43 pounds - all of it fat. My Body fat is now 12%. I also no longer spend $400 a month on supplements.
Jerry McBride, Philadelphia, PA
I bought Burn The Fat last October and I'm now so low in body fat you can see the striations. I've often been lean in the past, but never like this. This is Brad Pitt in Fight Club low! I have a hip-bone skinfold pinch of 2.0 mm, which on the accumeasure chart = 4.5% body fat. I couldn't be more pleased.
David Samuel London, UK
I started the program at 254 lbs and 36% body fat. I am now down to 214 lbs and 22% bodyfat, so I have lost 44 lbs of fat and gained 5 lbs of lean body mass. "
Dave Mullen, Gibsonia, PA
Thank God for your program because I've only been on it for just over a week and I'm already seeing results. I'm fitting into pants that I couldn't get into a 7 days ago. It's a wonderful thing to finally find something that works. "
Tracy Heptin, USA
Burn The Fat Feed the Muscle (BFFM) has changed my life. I have lost 3 dress sizes in 4 months and feel better than ever before. I now have my husband on the program. If we can do it with 4 kids and full time jobs -- anyone can.
Lynn Ramirez, California, USA
I like the nutrition program because I can customize it to my liking. I never get bored.
Joanna Crowe, B.C., Canada
What Makes This Fat Burning Breakthrough So Exciting is That it Gives You The Power To...
Lose fat permanently. It's a fact - 95% of the people who go on conventional diets gain all the weight back and sometimes they end up fatter than when they started. Now you can learn how to be in the successful 5% group that keeps it off forever. Lose body fat without wrecking your metabolism. If you've ever started a diet, then smashed into the dreaded "plateau," it's probably because you cannibalized your own muscle and slowed down your metabolism. Not only will this system teach you the only way to prevent your metabolism from crashing, you will also learn more than a dozen ways to fire up your "metabolic engine" and accelerate your body's natural rate of calorie-burning. Lose fat without drugs. When you mention bodybuilders, some people think of steroids or fat burning drugs. It's sad but true - most pro bodybuilders take them. But the joke's on them. Drugs work, but the results are temporary and the side effects are nasty. The tiny handful of natural bodybuilders who have learned how to use training and nutrition science to alter body composition without drugs are the only people in the world who keep their fat loss and muscle gains permanently. Now you can learn these fat burning secrets from a natural bodybuilding champion who knows from real-world experience exactly how it's done. Lose fat without supplements. 97% of all supplements are a total waste of money! You are being lied to and ripped off by crooked companies that don't give a rat's ass about your health and well-being. If you want to learn the ugly truth about the $13 billion per year supplement industry, and the $40 billion per year weight loss industry, then read every word of this report because it could save you thousands of your hard-earned dollars! Who I Am And Why You Should Listen to Me
There are thousands of diet programs and dozens of people claiming to be experts. However, very few of these so-called "Fat loss experts" practice what they preach or have the credentials and track record to back up their claims. Since you're probably wondering how this program is different, here's the whole story:
I've been bodybuilding for 23 years and competing for 17 years. I've been involved in the fitness industry as a personal trainer, health club manager, nutritionist, motivation coach and freelance writer for nearly 18 years. Bodybuilding and fitness is my life - it's all I've ever done.
"Tom Venuto, in my opinion, is the leading, VERY BEST fitness expert and author of our time and much of my and our client's success are due to his teachings. He and his fat loss system are on the cutting edge of science and don't miss a nutritional tip, trick, secret, or strategy in achieving amazing results. What's more, they are offered in an easy-to-understand and easy-to-follow format.
Chad Tackett, BS, CPT President/CEO Global-Fitness.com chad @ global-fitness.com
You may have seen my photos or articles in some of the magazines or on the Internet: I've been in IRONMAN, Muscular Development, Natural Bodybuilding & Fitness, Olympian's News (in Italian), Exercise for Men and Men's Exercise. I've written over 190 articles on bodybuilding, fat loss and fitness and you can find my articles featured on dozens of websites worldwide including Bodybuilding.com, Female Muscle.com, About.com, Lee Labrada's Lean Body Coaching Club, Will Brink's Muscle Building Nutrition.com, Global Health & Fitness.com, A to Z Fitness.com, and too many others to mention.
I have a BSc. degree in exercise science, I'm a certified strength and conditioning specialist (CSCS) and a certified personal trainer (NSCA-CPT). I'm a member of the International Society for Sports Nutrition (ISSN), the American College of Sports Medicine (ACSM) and the National Strength And Conditioning Association (NSCA). I'm a competitive bodybuilder and I've won three state and three regional championships. I've even gone as far as 2nd place in the Mr. Natural USA and 2nd in the Mr. Natural North America contests.
One more thing - and this is important - I'm a "lifetime natural" bodybuilder. "Natural" means I've never used steroids or any other banned or illegal physique enhancing drugs - ever! You can achieve AMAZING results on this program without ever taking drugs - and I'm living proof!
Friday, March 2, 2007
Primobolan
Primobolan
Primobolan is one of those anabolic steroids which has a cult following not unlike the old original version of Masteron. Actually, as you can easily see from it´s anabolic:androgenic ratio below in the profile, it´s a pretty weak steroid but actually stronger(!) than Masteron in both regards. I don´t know anyone who has run both compounds at the same dose. We are probably justified in speculating that you´d probably get similar results from either of them, when you consider the fact that you are getting quite a bit less actual drug and more ester when you choose injectable Primobolan (which has the very long Enanthate ester attached to it) over Masteron (which has the very short propionate ester attached to it). In truth, I think part of the reason many Primobolan users have been disappointed is that they failed to use enough of it, for long enough. From it´s chemical structure and anabolic:androgenic rating, we can assume it is at least as effective as Masteron, on an equal Mg for mg basis. However, due to its ester (in the injectable version), it needs to be run for at least 12 weeks to see the full benefits from it. When you consider a measly dose of 400mgs ofthis stuff for 12 weeks will probably cost you around $500.
Primobolan is one of those anabolic steroids which has a cult following not unlike the old original version of Masteron. Actually, as you can easily see from it´s anabolic:androgenic ratio below in the profile, it´s a pretty weak steroid but actually stronger(!) than Masteron in both regards. I don´t know anyone who has run both compounds at the same dose. We are probably justified in speculating that you´d probably get similar results from either of them, when you consider the fact that you are getting quite a bit less actual drug and more ester when you choose injectable Primobolan (which has the very long Enanthate ester attached to it) over Masteron (which has the very short propionate ester attached to it). In truth, I think part of the reason many Primobolan users have been disappointed is that they failed to use enough of it, for long enough. From it´s chemical structure and anabolic:androgenic rating, we can assume it is at least as effective as Masteron, on an equal Mg for mg basis. However, due to its ester (in the injectable version), it needs to be run for at least 12 weeks to see the full benefits from it. When you consider a measly dose of 400mgs of
this stuff for 12 weeks will probably cost you around $500.
It´s easy to see why many people have tried to use less...and have been disappointed with their results. On the other hand, many competitive bodybuilders consider Primobolan indespensible to their pre-contest drud routine, and wouldn´t consider dieting without it. Anyway...I think the comparison to Masteron (another great precontest drug) is the best one we can make, with reference to expected gains and results.
I happen to be one of the few people who have used Drostanolone Enanthate (Masteron with the Enanthate ester attached) as well as Methenolone Enanthate (injectable Primobolan). I can tell you that the results from these two compounds, when ester and mg potency are the same, are in fact very similar.
Effects of Primobolan
Let´s flesh out some of the various general effects of Primobolan, before we get into the differences between the oral and injectable versions... One study performed on sheep involved administering 100mgs of Methenolone, and electronically stimulating their lats (electronic stimulation was used because they kept falling off the chin-up bars). Anyway, when compared with the lat muscles of sheep who didn´t receive Methenolone, the receiving group gained significantly more muscle mass as well as strength (1)(2). It´s also has a relatively high affinity for binding to the AR, actually binding better than testosterone (3). This ability to strongly bind to the AR may be why Primobolan is such a good "fat burner." Strong AR binding has been positively correlated with lypolysis (fat-burning) (8).
In addition, as this steroid can actually aid in reducing breast tumors, no ancillary products need be considered for use with Primobolan, and in fact, it may actually be a useful ancillary agent in it´s own right, similar to Masteron. Also, just like Masteron, Primobolan has no propensity to aromatize (convert to estrogen). Since it doesn´t aromatize, alot of the side effects commonly associated with estrogen will not be of concern. This means water retention, acne, and gyno will be non-existent more or less. this lack of water retention combined with the slow and steady gains provided by Primo may help to explain why it has earned a reputation for creating quality muscle gains. This also helps to explain why it is so expensive. Although estrogenic sides are not a concern, hair loss still, remains a very real concern with Primobolan, as with many DHT-Derived steroids. Many primobolan fans always include Finasteride and Ketoconazole (shampoo) in cycles containing Primobolan.
Although nobody would ever suggest to use Primobolan as a bulking agent, it´s been studied as an agent to halt wasting and possibly reverse many of the adverse effects of anemia. It is a shocking failure in both areas, according to some of the case studies I´ve read, (5)(6) and this should come to no surprise to anyone. Anadrol reigns supreme in this area, and nobody in the athletic community would ever compare those two drugs. However, Michael Mooney and many other respected doctors who work with AIDS patients have found sufficient evidence to claim that Primobolan is an immune enhancer and as such is very useful for AIDS patients (not that the FDA cares...Primobolan is still not approved for sale in the United States). AIDS patients aren´t really in need of Bulking Drugs, so an immune enhancer like Primo which will add small, quality gains in muscle is perfect for them. And since we aren´t even going to vaguely consider the use of Primobolan as a bulking agent, clearly this leaves us with considering it primarily for use in gaining and maintaining lean tissue. It´s a great choice for this purpose, and many competitors have used it very successfully to retain muscle while on a calorie reduced diet. The reason Primo is so useful for this purpose is that one of its primary functions is to help your body retain nitrogen (7) at a greatly enhanced rate. The greater your nitrogen retention is, the more muscle you will build. In the case of using primo as a pre-contest drug, this nitrogen retention will help you retain muscle and ensure that your dieting preferentially favors fat loss over muscle loss.
Primobolan is a very unique steroid, as it is one of the few that comes in both an oral as well as an injectable version. I suppose Winstrol does also, but Primobolan actually has a different ester on the oral (acetate ) and injectable (Enanthate) versions. The oral version is one of the more interesting oral compounds I´ve looked into. For starters, it´s one of the few compounds available to athletes and bodybuilders which is both oral as well as non-17-alpha-alkylation. This alteration is (as I´m sure you remember from other stuff I´ve written) what generally makes oral steroids survive their first pass through your liver, but also makes them Hepatoxic (Liver toxic). Well... oral Primo doesn´t have this feature, so it is very mild on your liver (actually it basically isn´t liver toxic at all), but also is largely destroyed by it, since 17 beta estrification and 1 alkylation is the method used to make this stuff orally available. You´ll need to take a lot of this stuff for it to be effective... 100mgs/day of the oral version is a safe estimate for reasonable gains& for women, you could get away with less; perhaps 25mgs/day. Even though the acetate ester has a 2-3 day active life, your liver will do some damage to oral primo, so every day dosing will still be necessary.
When men were given a 30-45mg dose of the oral version of Primo, they experienced a 15-65% decrease in gonadotropin levels (9). Remember, I said 100mgs is a good dose for gains... well, you´ll also reduce your gonadotropin levels considerably. I have personally never understood why people recommend either oral or injectable Primobolan as a possible bridging compound for this reason... maybe at a too-low-to-do-anything dose of 10mgs it could be used as a bridge. And forget about using injectable Primo to bridge&
Hey... speaking about injectable Primo...
I´ve used this stuff at 200mgs/week and wasn´t very impressed with it. Generally, I think injectable primo needs to be used at a dose of at least 350mgs/week (100mgs/Every other Day), and preferably at a dose of 400-600mgs/week. I happen to like running it with testosterone propionate, but for convenience I would imagine most people would run it with Testosterone Enanthate, to keep dosing times the same (shooting it twice per week, in most cases).
Buying Primobolan
The unfortunate truth about injectable Primo is that it´s a very expensive chemical to obtain, and that price is reflected in the cost to the average consumer. Ten dollars per 1ml/100mg ampule is not unheard of, and I´ve seen it go for more. This is, of course, absurd. As if that´s not enough, this is also the most commonly counterfeited steroids on the black market. I recommend buying Primobolan (either the oral or injectable) from a respected Underground lab instead of trying to play a game of "spot the fake steroid" in Mexico or Europe. The underground versions should cost between $5-7 for 100mgs of Methenolone and I wouldn´t really consider paying more for it, although I have seen the British Dragon version of this product priced up to $20/ml.
Primobolan Profile
(Methenolone) (Oral Version is + Acetate Ester) (Injectable Version is + Enanthate Ester) [17beta-Hydroxy-1-methyl-5alpha-androst-1-en-3-one] Molecular weight of base: 302.4558 Molecular weight of Acetate ester: 60.0524 Molecular weight of Enanthate ester: 130.1864 Formula: C20H30O2 Melting Point: Manufacturer: Schering Effective dose(oral): (Men)50-100mgs/day; (Women) 10-25mgs/day Effective dose (injectable): (Men) 350-600mgs/week; (Women) 100mgs/week Active Life: 10-14 days (injectable); 4-6hrs (oral) Detection Time: 4-5 weeks Anabolic/Androgenic Ratio (Range): 88:44-57
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